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Multifunctional nanostructures: Intelligent design to overcome biological barriers
Mehdi Azizi1,2, Rana Jahanban-Esfahlan3, Hadi Samadian2,4
1Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.
Materials Today. Bio
|June 5, 2023
Summary
Nanoscience offers solutions for chemotherapy but faces challenges in nanoparticle delivery. This review explores nanobioengineering strategies to overcome tumor barriers and improve drug efficacy for clinical nanoformulations.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nanoscience has advanced chemotherapy by reducing toxicity and improving drug efficiency.
- Poor nanoparticle accumulation and pharmacokinetics hinder clinical translation.
- Tumor characteristics and nanoparticle interactions compromise drug delivery.
Purpose of the Study:
- To review barriers and solutions for nanoparticle drug delivery.
- To discuss nanobioengineering strategies for nanocarriers and the tumor environment.
- To evaluate methods for overcoming multiple biological barriers with single nanocarriers.
Main Methods:
- Review of current literature on nanoscience and drug delivery.
- Analysis of nanobioengineering approaches for nanocarrier design.
- Evaluation of strategies targeting tumor microenvironments.
Main Results:
- Enhanced permeability and retention (EPR) effect efficacy is estimated at only 1%.
- Tumor features may not be as beneficial for nanoparticle delivery as previously thought.
- Various nanocarrier designs and strategies exist to improve drug delivery.
Conclusions:
- Overcoming biological barriers is crucial for effective nanoparticle drug delivery.
- Nanobioengineering offers promising solutions for improving nanoformulations.
- Further research is needed to translate nanoformulations into clinical applications.
