The effect of new adamantane derivatives on experimental influenza infection in mice

Two newly synthesized derivatives of 1-aminoadamantane hydrochloride--CF.01.01 and CF.01.06--were assayed for their anti-influenza efficacy. Aqueous solutions of the drugs (200 gamma/0.1 ml) were administered intranasally to mice at 24 hours and 5 hours or at 24 hours, 5 hours and 1 hour prior to intranasal inoculation of influenza virus A/PR/8/34 (H1N1). Compound CF.01.06 caused a significant decrease of the HA titer in the lungs of virus-infected mice. There was no change in mortality rate and the increase in mean survival time was at the limit of statistical significance.