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Impaired Cardiovascular Response to Exercise in Patients with Severe Asthma: A Case-Control Study
Athina Georgopoulou1,2, Laskarina Fotiadou1, Stavros Tryfon1
1Department of Respiratory Medicine, G. Papanikolaou Hospital, Thessaloniki, Greece.
The Open Respiratory Medicine Journal
|June 5, 2023
Summary
Severe asthma patients show lower cardiovascular reserve (double product) during exercise compared to mild-moderate asthma patients. This double product may help assess cardiovascular function in asthma management.
Area of Science:
- Cardiology
- Pulmonology
- Exercise Physiology
Background:
- Asthma patients often have reduced exercise capacity, but their cardiovascular responses during exercise are understudied.
- Cardiovascular reserve, measured by double product (DP), is a key indicator of cardiac function during physical exertion.
Purpose of the Study:
- To investigate differences in double product (DP) between severe and mild-moderate asthma patients.
- To explore the association of DP with asthma control, physical activity (PA), and exercise capacity in asthmatics.
Main Methods:
- A case-control study comparing severe (group S) and mild-moderate (group M) asthma patients.
- Participants completed questionnaires (asthma control, PA), lung function tests, and a six-minute walk test (6MWD).
- Cardiovascular responses, including DP, exercise capacity (6MWD), and PA levels, were recorded.
Main Results:
- Severe asthma patients exhibited significantly lower DP at exercise completion compared to mild-moderate patients (p=0.041).
- DP was moderately associated with % predicted 6MWD (r=0.592; p=0.001).
- Severe asthma patients reported lower moderate-intensity PA, yet exercise capacity was similar between groups; asthma control did not impact these parameters.
Conclusions:
- Severe asthma may be linked to impaired cardiovascular reserve (DP) even with comparable exercise capacity to milder cases.
- DP serves as an accessible parameter for evaluating cardiovascular function in asthma patients.
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