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A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
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Does COVID-19 vaccination protect against pulmonary embolism?
Simona Tantillo1, Nicola Cilloni1, Martina Guarnera1
1Bologna, Italy Department of Anaesthesia, Intensive Care and EMS, Ospedale Maggiore "Carlo Alberto Pizzardi".
Journal of Anesthesia, Analgesia and Critical Care
|June 5, 2023
Summary
COVID-19 vaccination may protect hospitalized patients from pulmonary embolism (PE). Vaccinated individuals showed significantly lower PE prevalence and disease severity compared to unvaccinated patients in this study.
Area of Science:
- Pulmonary Medicine
- Infectious Diseases
- Vaccinology
Background:
- Venous thromboembolism (VTE) prevalence in COVID-19 patients varies significantly.
- The potential protective effect of vaccination against pulmonary embolism (PE) in hospitalized COVID-19 patients remains under-explored.
Purpose of the Study:
- To investigate and compare the prevalence of PE in vaccinated versus unvaccinated hospitalized COVID-19 patients.
Main Methods:
- Retrospective case-control study conducted between November 2021 and January 2022.
- Inclusion of 62 hospitalized COVID-19 patients undergoing chest CT for suspected PE.
- Analysis of PE diagnosis, CT Severity Score (CT-SS), and patient demographics (age, comorbidities).
Main Results:
- Overall PE prevalence was 30.1% (19/62 patients).
- Unvaccinated patients exhibited a significantly higher PE prevalence (45.7%) compared to vaccinated patients (11.1%), with an odds ratio (OR) of 0.04.
- Unvaccinated patients also showed more severe CT imaging findings (CT-SS).
Conclusions:
- A strong association exists between COVID-19 vaccination and protection against PE in hospitalized patients.
- Vaccination was linked to significantly lower morbidity from PE in this cohort.
- Further prospective studies are warranted to confirm the protective role of vaccination against COVID-19-associated VTE.
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