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Updated: Jul 27, 2025

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Idiopathic sclerosing mesenteritis presenting with small bowel volvulus in a patient with antiphospholipid syndrome:
Papawee Chennavasin1, Montri Gururatsakul2
1Department of Surgery, Chulabhorn Hospital, Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok 10210, Thailand. papawee.che@cra.ac.th.
Background:
Sclerosing mesenteritis is a rare disorder involving inflammation of the mesentery. Its etiology remains unclear, but it is believed to be associated with previous abdominal surgery, trauma, autoimmune disorders, infection, or malignancy. Clinical manifestations of sclerosing mesenteritis are varied and include chronic abdominal pain, bloating, diarrhea, weight loss, formation of an intra-abdominal mass, bowel obstruction, and chylous ascites. Here, we present a case of idiopathic sclerosing mesenteritis with small bowel volvulus in a patient with antiphospholipid syndrome.
Case Summary:
A 68-year-old female presented with recurrent small bowel obstruction. Imaging and pathological findings were consistent with sclerosing mesenteritis causing mesenteric and small bowel volvulus. Computed tomography scans also revealed pulmonary embolism, and the patient was started on a high dose of corticosteroid and a therapeutic dose of anticoagulants. The patient subsequently improved clinically and was discharged. The patient was also diagnosed with antiphospholipid syndrome after a hematological workup.
Conclusion:
Sclerosing mesenteritis is a rare condition, and patients with no clear etiology should be considered for treatment with immunosuppressive therapy.
Insights
Idiopathic sclerosing mesenteritis, a rare mesenteric inflammation, can cause bowel obstruction. This case highlights successful treatment with corticosteroids and anticoagulants for a patient with antiphospholipid syndrome.
Area of Science:
- Gastroenterology
- Rare Diseases
- Autoimmune Disorders
Background:
- Sclerosing mesenteritis is a rare inflammatory disorder of the mesentery with unknown etiology.
- It presents with diverse symptoms including abdominal pain, bowel obstruction, and weight loss.
- Potential associations include surgery, trauma, autoimmune conditions, infection, or malignancy.
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