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Updated: Jul 27, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
Telomere biology: from disorders to hematological diseases
Kleoniki Roka1, Elena E Solomou2, Antonis Kattamis1
1Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National & Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Full Member of ERN GENTURIS, Athens, Greece.
Abstract:
Variations in the length of telomeres and pathogenic variants involved in telomere length maintenance have been correlated with several human diseases. Recent breakthroughs in telomere biology knowledge have contributed to the identification of illnesses named "telomeropathies" and revealed an association between telomere length and disease outcome. This review emphasizes the biology and physiology aspects of telomeres and describes prototype diseases in which telomeres are implicated in their pathophysiology. We also provide information on the role of telomeres in hematological diseases ranging from bone marrow failure syndromes to acute and chronic leukemias.
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