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Related Experiment Videos

Basile Konmy1,2,3, Pascal Abiodoun Olounladé1,3, Tomabu Adjobimey4

  • 1Zootechnical Research and Livestock System Unit, School of Management and Operation of Livestock Systems, National University of Agriculture, Porto-Novo, Benin.

Frontiers in Cellular and Infection Microbiology
|June 5, 2023
PubMed
Summary

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This summary is machine-generated.

Moringa oleifera and Vernonia amygdalina extracts show high anticoccidial activity against Eimeria species in rabbits. These natural compounds also enhance immune responses, offering a promising alternative to synthetic anticoccidials in rabbit farming.

Area of Science:

  • Veterinary Parasitology
  • Immunology
  • Phytochemistry

Background:

  • Coccidiosis, caused by Eimeria species, is a significant parasitic disease in rabbits.
  • Synthetic anticoccidials face challenges like resistance and residue concerns.
  • Natural alternatives are sought to manage coccidiosis and boost host immunity.

Purpose of the Study:

  • To evaluate the anticoccidial efficacy of Moringa oleifera and Vernonia amygdalina leaf extracts.
  • To assess the immune-modulating effects of these plant extracts in rabbits infected with Eimeria magna and Eimeria media.
  • To explore their potential as natural alternatives to synthetic anticoccidials.

Main Methods:

  • Rabbits were experimentally infected with Eimeria magna and Eimeria media oocysts.
Keywords:
Eimeria magnaEimeria mediaMoringa oleiferaVernonia amygdalinaanticoccidial activityimmune response

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  • Acetone extracts of Moringa oleifera and Vernonia amygdalina were administered orally at various doses.
  • Oocyst excretion was quantified using the McMaster technique.
  • Immune response markers, including IL-4, IL-12, and IgG, were measured via ELISA.

    • Main Results:

    • Both Moringa oleifera and Vernonia amygdalina extracts demonstrated high in vivo efficacy against Eimeria oocysts (95.43% and 96.53%, respectively) at 1000 mg/kg body weight.
    • Plant extracts significantly increased the production of interleukin (IL)-4, IL-12, and immunoglobulin (Ig)G compared to control groups.
    • The extracts showed comparable efficacy to the positive control, reaching 98% inhibition of oocyst excretion.

    Conclusions:

    • Moringa oleifera and Vernonia amygdalina possess significant anticoccidial activity and immunomodulatory properties.
    • These plant extracts represent a viable natural alternative to synthetic anticoccidials for controlling coccidiosis in rabbits.
    • Their use can enhance rabbit immunity against Eimeria infections, benefiting rabbit farming operations.