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Association between Bisphenol A exposure and body composition parameters in children
Yong Guo1, Cui Liu1, Yu-Hong Deng1
1Department of Children's Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
Insights
Bisphenol A (BPA) exposure in young children is linked to increased body mass index, fat mass, and percent body fat. This study highlights potential obesity risks in children due to BPA, emphasizing the need for further research.
Area of Science:
- Environmental Health
- Pediatric Health
- Toxicology
Background:
- Limited research exists on Bisphenol A (BPA) exposure and body composition in young children.
- Existing evidence suggests a link between BPA exposure and obesity.
Purpose of the Study:
- To investigate the association between BPA exposure and body composition parameters in preschool children.
- To assess potential risks of BPA on child obesity development.
Main Methods:
- Cross-sectional study of 200 children aged 4-6 years in Guangzhou, China.
- Urinary BPA levels measured using ultra-high performance liquid chromatography-tandem mass spectrometry.
- Body composition assessed via bioelectrical impedance analysis (InBody770).
Main Results:
- BPA levels were significantly associated with higher body mass index, body fat mass, fat free mass, and percent body fat.
- Positive linear associations were found between BPA concentration quartiles and body composition parameters.
- Adjusted models confirmed significant correlations between BPA exposure and adverse body composition.
Conclusions:
- BPA exposure is positively correlated with unfavorable body composition parameters in young children.
- Findings suggest potential health risks related to obesity in children exposed to BPA.
- Further research is warranted to confirm these associations and elucidate underlying mechanisms.
Background:
Although there is evidence linking Bisphenol A (BPA) exposure to obesity, research examining its relationship with body composition parameters in young children is limited.
Methods:
A cross-sectional investigation was conducted on 200 preschool children aged between 4 and 6 years in Guangzhou, China. BPA exposure was assessed through urine samples using ultra-high performance liquid chromatography- tandem mass spectrometry, and body composition parameters were measured through bioelectrical impedance analysis (InBody770).
Results:
The median urinary BPA concentration was 0.556 μg/L (IQR: 0.301 - 1.031 μg/L) and creatinine-adjusted BPA concentration was 0.930 μg/g (IQR: 0.551 - 1.586 μg/g). BPA levels were significantly associated with body mass index (β= 1.15; 95%CI: 0.47, 1.83), body fat mass (β= 1.14; 95%CI: 0.39, 1.89), fat free mass (β= 0.92; 95%CI: 0.26, 1.58), and percent body fat (β= 3.44; 95%CI: 1.17, 5.71) after adjusting for potential confounding factors. Similarly, adjusted models with log10-transformed creatinine-adjusted BPA concentrations as a continuous variable showed similar trends. Positive linear associations were observed between quartiles of BPA concentrations and body composition parameters, with the highest coefficients in the fourth quartile.
Conclusion:
Our study provides further evidence of positive correlations between BPA exposure and body composition parameters in children aged 4 to 6 years. These findings highlight the potential health risks associated with obesity-related body composition parameters in young children. Further investigations are needed to confirm this association and explore the underlying mechanisms.
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