Hydroxyapatite-based carriers for tumor targeting therapy

At present, targeted drug delivery is regarded as the most effective means of tumor treatment, overcoming the lack of conventional chemotherapeutics that are difficult to reach or enter into cancer cells. Hydroxyapatite (HAP) is the main component of biological hard tissue, which can be regarded as a suitable drug carrier due to its biocompatibility, nontoxicity, biodegradation, and absorbability. This review focuses on the cutting edge of HAP as a drug carrier in targeted drug delivery systems. HAP-based carriers can be obtained by doping, modification, and combination, which benefit to improve the loading efficiency of drugs and the response sensitivity of the microenvironment in the synthesis process. The drug adsorbed or in situ loaded on HAP-based carriers can achieve targeted drug delivery and precise treatment through the guidance of the in vivo microenvironment and the stimulation of the in vitro response. In addition, HAP-based drug carriers can improve the cellular uptake rate of drugs to achieve a higher treatment effect. These advantages revealed the promising potential of HAP-based carriers from the perspective of targeted drug delivery for tumor treatment.