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Austalide derivative from marine-derived

Mohamed S Elnaggar1,2, Ahmed M Elissawy1,3, Fadia S Youssef1

  • 1Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University Abbassia 11566 Cairo Egypt aelissawy@pharma.asu.edu.eg dean@pharma.asu.edu.eg.

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Researchers discovered new compounds from Aspergillus fungi, including austalide Z, with potential for cancer prevention. These natural products show promising properties for drug development.

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Area of Science:

  • Natural Product Chemistry
  • Marine Biotechnology
  • Pharmacology

Background:

  • Soft corals are a rich source of bioactive natural products.
  • Fungi, including Aspergillus species, can produce complex secondary metabolites.
  • Meroterpenoids and alkaloids from marine-associated fungi are of interest for drug discovery.

Purpose of the Study:

  • To isolate and characterize chemical constituents from Aspergillus sp. associated with the soft coral Sinularia species.
  • To evaluate the cytotoxic activity of the isolated compounds against the Caco-2 cancer cell line.
  • To assess the drug-likeness of the compounds using in silico ADME/TOPKAT predictions.

Main Methods:

  • Chemical investigation using ethyl acetate extract of Aspergillus sp.
  • Structure elucidation via 1D and 2D NMR, UV, and ESI-MS.
  • In vitro cytotoxicity assay (MTT) and in silico ADME/TOPKAT analysis.

Main Results:

  • Isolation of one new meroterpenoid, austalide Z (1), and ten known compounds.
  • Austalide Z (1) exhibited weak to moderate cytotoxicity against Caco-2 cells (IC50 = 51.6 μg mL-1).
  • In silico analysis indicated favorable pharmacokinetic, pharmacodynamic, and toxicity profiles for most compounds.

Conclusions:

  • Aspergillus sp. associated with soft corals can yield novel bioactive compounds.
  • Austalide Z and other isolated compounds represent potential drug leads for cancer prevention.
  • The identified compounds possess promising properties for pharmaceutical applications.