Stimuli-responsive nanocarrier delivery systems for Pt-based antitumor complexes: a review

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Platinum-based drugs are vital cancer treatments but face limitations like toxicity and resistance.
• Drug delivery systems are crucial for enhancing chemotherapy efficacy and minimizing side effects.

Purpose of the Study:

• To review recent advances in stimuli-responsive nanocarrier drug delivery systems for platinum-based anticancer drugs.
• To highlight strategies for improving drug efficacy and reducing toxicity.

Main Methods:

• Review of current literature on stimuli-responsive nanocarriers for platinum-based chemotherapy.
• Categorization of nanocarriers based on responsive triggers (endogenous and extracorporeal).

Main Results:

• Significant progress has been made in developing stimuli-responsive nanocarriers for platinum drugs.
• Endogenous stimuli (pH, temperature, enzymes, redox) and extracorporeal stimuli (light, magnetic fields, ultrasound) are employed.
• These systems show potential for targeted drug release and improved therapeutic outcomes.

Conclusions:

• Stimuli-responsive nanocarriers represent a promising strategy to enhance platinum-based chemotherapy.
• Further research in this area can lead to more effective and safer cancer treatments.