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Role of

Kang Huang1, Tianyi Ma1, Qiang Li1

  • 1Department of Cardiology, Haikou People's Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, Hainan, 570100, People's Republic of China.

Pharmacogenomics and Personalized Medicine
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Genetic variations in CYP19A1, specifically rs28757157 and rs3751591, are linked to ischemic stroke (IS) risk in the Chinese Han population. These findings offer insights into the genetic underpinnings of IS.

Keywords:
CYP19A1Chinese Han populationcase-control studyischemic strokerisksingle nucleotide polymorphisms

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Area of Science:

  • Genetics
  • Neurology
  • Cardiovascular Disease

Background:

  • Ischemic stroke (IS) is a complex disease influenced by multiple genetic factors.
  • The role of specific gene polymorphisms in IS susceptibility requires further investigation.

Purpose of the Study:

  • To investigate the association between CYP19A1 single nucleotide polymorphisms (SNPs) and the risk of ischemic stroke (IS) in the Chinese Han population.

Main Methods:

  • A case-control study included 1302 subjects (651 cases, 651 controls).
  • Four candidate CYP19A1 SNPs (rs28757157, rs3751592, rs3751591, rs59429575) were analyzed using logistic regression.
  • SNP-SNP interactions were assessed using multi-factor dimensionality reduction (MDR).

Main Results:

  • CYP19A1 loci rs28757157 and rs3751591 were significantly associated with IS risk.
  • These variants increased IS susceptibility in individuals over 60, smokers, and drinkers.
  • Rs28757157 showed associations in females and non-smokers, while rs59429575 was linked to males and higher BMI.

Conclusions:

  • Significant associations were found between CYP19A1 SNPs (rs28757157 and rs3751591) and IS risk in the Chinese Han population.
  • These findings provide a genetic basis for understanding IS pathogenesis.