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Modulation of T cell function and survival by the tumor microenvironment
Nikita Mani1, Dathan Andrews2, Rebecca C Obeng2,3,4
1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Frontiers in Cell and Developmental Biology
|June 5, 2023
Summary
Cancer immunotherapy relies on T cells, but the tumor microenvironment (TME) presents challenges. Understanding TME factors is key to improving T cell function for better cancer treatment responses.
Area of Science:
- Immunology
- Oncology
- Cancer Biology
Background:
- Cancer immunotherapy represents a significant advancement in cancer treatment.
- T cells are crucial for effective antitumor immunity and sustained clinical responses.
- The tumor microenvironment (TME) comprises diverse cells that influence T cell activity.
Purpose of the Study:
- To discuss factors modulating T cell function and survival within the TME.
- To highlight the impact of TME complexity on antitumor immune responses.
- To identify key interactions affecting T cell efficacy in cancer.
Main Methods:
- Review of existing literature on T cell interactions within the TME.
- Analysis of factors influencing T cell function, including cellular components, tumor biology, and metabolism.
- Discussion of the interplay between tumor characteristics and T cell responses.
Main Results:
- The TME contains a complex cellular milieu impacting T cell function and survival.
- Tumor biology, structural features, nutrient availability, and metabolism significantly affect T cell quality.
- Interactions within the TME are critical determinants of the overall antitumor immune response.
Conclusions:
- Achieving robust and durable T cell responses is challenging due to TME complexity.
- Modulating T cell function within the TME is essential for enhancing immunotherapy efficacy.
- Further research into TME-T cell dynamics can optimize cancer treatment strategies.
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