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Updated: Jul 27, 2025

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

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Engineered Protein-Iron Oxide Hybrid Biomaterial for MRI-traceable Drug Encapsulation.

Lindsay K Hill^1,2,3,4, Dustin Britton¹, Teeba Jihad¹

¹Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA.

Molecular Systems Design & Engineering

|June 5, 2023

Summary

Researchers developed a novel protein-iron oxide hybrid material for biomedical imaging and drug delivery. This biomaterial enables non-invasive monitoring via MRI and can encapsulate drugs like doxorubicin.

Keywords:

MRI biomineralization drug encapsulation fiber iron oxide protein engineering

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Area of Science:

Biomaterials Science
Nanotechnology
Biomedical Engineering

Background:

Protein-based biomaterials are utilized in tissue engineering, therapeutics, and diagnostics.
Ultrasmall super-paramagnetic iron oxide (USPIO) nanoparticles enable advanced imaging techniques like MRI.
Current USPIO-biomaterial conjugates often use harsh synthesis conditions and primarily serve diagnostic roles.

Purpose of the Study:

To create a novel protein-iron oxide hybrid biomaterial using mild conditions.
To develop a material for both biomedical imaging and drug delivery applications.
To explore the use of a rationally designed coiled-coil protein as a building block for meso-scale fibers.

Main Methods:

Engineered an azide-functionalized coiled-coil protein (Q) with small molecule binding capacity.
Conjugated the protein to an alkyne-bearing iron oxide templating peptide (CMms6) via bioorthogonal azide-alkyne cycloaddition.
Utilized the construct for USPIO biomineralization under mild conditions and doxorubicin encapsulation.

Main Results:

Successfully synthesized a protein-iron oxide hybrid material under mild conditions.
Demonstrated doxorubicin encapsulation capability within the hybrid material.
Achieved sensitive T2*-weighted MRI darkening, indicating strong imaging capability derived from the coiled-coil protein.

Conclusions:

The engineered protein-iron oxide hybrid material offers a versatile platform for biomedical applications.
This novel biomaterial combines diagnostic imaging (MRI) and therapeutic delivery (doxorubicin encapsulation).
The use of bioorthogonal chemistry and a rationally designed protein enables mild synthesis and unique material properties.