Identification of Novel
Ran Duan1, Xiaojin Zheng2, Qun Duan1
1State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
China CDC Weekly
|June 5, 2023
Summary
Bartonella washoensis (B. washoensis) bacteria were found in one-third of Himalayan marmots, primarily in their heart and lungs. This finding highlights potential public health risks in marmot habitats.
Area of Science:
- Zoonotic diseases
- Microbiology
- One Health
Background:
- Rodent-adapted Bartonella species prevalence is increasing.
- The Bartonella species harbored by Himalayan marmots (Marmota himalayana) and associated human health risks are largely unknown.
Purpose of the Study:
- To identify Bartonella species in Marmota himalayana.
- To assess the potential public health implications of Bartonella infections in this rodent population.
Main Methods:
- Molecular detection of Bartonella DNA in M. himalayana samples.
- Analysis of Bartonella species prevalence and tissue distribution.
- Genetic characterization of identified Bartonella isolates, including novel sequence types.
Main Results:
- Bartonella washoensis (B. washoensis) was detected in approximately one-third of M. himalayana.
- B. washoensis showed a predilection for the heart and lungs.
- A novel Sequence Type 22 of B. washoensis was identified, expanding its known genetic diversity and isolation sources.
Conclusions:
- M. himalayana serves as a significant reservoir for B. washoensis.
- Individuals in M. himalayana plague focus areas face an increased risk of B. washoensis infection.
- Public health strategies are needed for early detection and prevention of B. washoensis in at-risk human populations.
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