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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
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Susceptibility patterns and virulence genotypes of

Ahmed Morad Asaad1, Gasser El-Azab2, Eman Abdelsameea2

  • 1Department of Microbiology, College of Medicine, Zagazig University, Zagazig 44519, Egypt.

World Journal of Gastroenterology
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

The 14-day triple therapy regimen for Helicobacter pylori (H. pylori) infection showed a low eradication rate of 59.2% in Egyptian patients. High H. pylori resistance to common antibiotics like metronidazole, amoxicillin, and clarithromycin presents a significant challenge for treatment success.

Keywords:
Clarithromycin resistanceEradication therapyHelicobacter pyloriVirulencecagA genevacA gene

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Helicobacter pylori (H. pylori) is a major pathogen causing gastric cancer, ulcers, and gastritis.
  • Understanding H. pylori prevalence and antibiotic resistance is crucial for effective treatment strategies.

Purpose of the Study:

  • To determine H. pylori infection frequency and resistance patterns in Egyptian patients.
  • To assess the impact of H. pylori virulence factors on 14-day triple therapy success.

Main Methods:

  • Investigated 72 patients with H. pylori-suggestive gastroduodenal issues.
  • Analyzed cagA and vacA genotypes using PCR.
  • Assessed treatment response via histology and rapid urease test 6 weeks post-therapy.

Main Results:

  • The intention-to-treat eradication rate was 59.2%.
  • H. pylori resistance rates: clarithromycin (52.8%), amoxicillin (81.9%), metronidazole (100%).
  • Successful eradication linked to vacA s1-positive strains; failed eradication associated with clarithromycin and amoxicillin resistance.

Conclusions:

  • Low eradication rates with 14-day triple therapy are concerning.
  • Widespread H. pylori resistance to metronidazole, amoxicillin, and clarithromycin complicates treatment.
  • Urgent need for updated H. pylori treatment guidelines considering resistance patterns.