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Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
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Short

Karampet Kasparian1,2, Chrysanthos D Christou3, Konstantinos Petidis4

  • 1Clinic of Oncology, Gastroenterology and Hematology, Alfried Krupp Hospital, Essen 45131, Germany.

World Journal of Gastroenterology
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

Shorter antibiotic courses for acute cholangitis (AC) appear as effective as longer durations regarding mortality and recurrence. This systematic review suggests current guidelines may be updated for optimal AC treatment duration.

Keywords:
Acute cholangitisAntibioticAntimicrobialLong-courseShort-courseTreatment duration

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Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Acute cholangitis (AC) is a serious infection with historically high mortality.
  • Advances in diagnostics and therapeutics have reduced AC mortality rates.
  • Optimal antibiotic treatment duration for AC remains an unresolved clinical question.

Approach:

  • A systematic review and meta-analysis evaluated existing literature on AC antibiotic therapy duration.
  • Fifteen studies were included in the review; eight were eligible for meta-analysis.
  • Patients were grouped by antibiotic treatment durations: 2-3 days, 6-7 days, and 14 days.

Key Points:

  • The meta-analysis included 1313 patients, with a mean age of 73.66 years.
  • No significant differences in mortality rates were observed between 2-3 day and longer antibiotic treatments (OR = 0.78, 95% CI: 0.23-2.67).
  • Recurrence rates and hospitalization length did not significantly differ across treatment groups.

Conclusions:

  • Short-course (2-3 days) and long-course antibiotic treatments demonstrate comparable efficacy for AC regarding mortality and recurrence.
  • Further research is needed to establish definitive conclusions on optimal hospitalization duration.
  • Findings suggest potential for shorter antibiotic regimens in AC management.