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Related Experiment Video

Updated: Jul 27, 2025

Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat
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Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat

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Stereotaxic cutting of

Miguel Ángel García-Cabezas1,2,3, Isabel Pérez-Santos1,2, Carmen Cavada1,2

  • 1Department of Anatomy, Histology and Neuroscience, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Frontiers in Neuroanatomy
|June 5, 2023
PubMed
Summary

Researchers developed a novel instrument for stereotaxic cutting of post-mortem human brains. This tool enables precise brain sectioning in stereotaxic coordinates, aiding neuroimaging research.

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Area of Science:

  • Neurosurgery
  • Neuroimaging
  • Neuroanatomy

Background:

  • Stereotaxis is crucial in neurosurgery, neuroradiosurgery, and neuroimaging.
  • A gap exists in presenting post-mortem human brain data in standard stereotaxic coordinates.
  • Standardized stereotaxic data facilitates comparisons between post-mortem and in vivo studies.

Purpose of the Study:

  • To present a novel instrument for stereotaxic cutting of post-mortem human brain hemispheres.
  • To enable the creation of human brain slabs within the Talairach and Tournoux stereotaxic space.
  • To detail a protocol for obtaining histological sections in stereotaxic coordinates.

Main Methods:

  • Development of a specialized instrument featuring a transparent methacrylate plate, mirror, legs, and columns for knife insertion.
Keywords:
Talairachhuman neuroanatomyintercommissural planestereotaxic instrumentstereotaxis

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  • Detailed procedure for stereotaxic cutting of human brain hemispheres in the coronal plane.
  • Methodology for calculating stereotaxic coordinates of resulting histological sections.

    • Main Results:

    • The instrument allows for the precise stereotaxic cutting of post-mortem human brain hemispheres.
    • Human brain slabs can be consistently produced in the Talairach and Tournoux stereotaxic space.
    • A protocol is established for determining the stereotaxic coordinates of histological sections.

    Conclusions:

    • The developed instrument and protocol provide a standardized method for processing post-mortem human brains.
    • This facilitates direct comparison of anatomical data with in vivo neuroimaging studies.
    • It enhances the reproducibility and comparability of neuroscientific research involving human brain anatomy.