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S Rahamouz-Haghighi1, Kh Bagheri1, N Mohsen-Pour2
1Department of Plant Production and Genetics, Faculty of Agriculture, University of Zanjan, Zanjan, Iran.
Archives of Razi Institute
|June 5, 2023
Summary
Ribwort plantain root extracts show significant cytotoxic and antibacterial properties. Phytochemical analysis reveals bioactive compounds, suggesting potential for pharmaceutical applications.
Area of Science:
- Phytochemistry
- Pharmacology
- Traditional Medicine
Background:
- Ribwort plantain (Plantago lanceolata L.) is a globally recognized herbal plant.
- It belongs to the Plantaginaceae family and has a history of use in traditional medicine.
Purpose of the Study:
- To investigate the bioactive substances in P. lanceolata root fractions.
- To evaluate the cytotoxic and antibacterial activities of P. lanceolata root extracts.
Main Methods:
- Cytotoxicity was assessed using the MTT assay.
- Antibacterial activity was determined by disc diffusion and microtiter broth dilution methods.
- Phytochemical profiling was performed using gas chromatography-mass spectrometry (GC-MS).
Main Results:
- Plant extracts exhibited cytotoxicity against HCT-116 cells, with IC50 values around 167-205 μg/mL.
- Dichloromethane extract showed the highest antibacterial effect against S. paratyphi.
- GC-MS analysis identified key compounds including 1,2-Benzenedicarboxylic acid and mono(2-ethylhexyl) ester.
Conclusions:
- P. lanceolata root extracts are rich in bioactive metabolites.
- These extracts demonstrate significant cytotoxic and antibacterial potential.
- The findings support the use of P. lanceolata in developing pharmaceutical materials.