Parasitic infections are one of the main problems in sheep breeding farms. For this reason, in order to control the damage caused by parasitic infections, a wide range of antiparasitic drugs with different forms are used. A particular area is important due to contamination with radioactive substances and its effect on the immune system of livestock in the area. Therefore, the aim of the present study was the effectiveness of antiparasitic drugs in sheep farms in Kazakhstan. In the current study, 3 groups of lambs were evaluated; each one included 30 infected lambs of 5 to 6 months with Strongyloides and Eimeria spp. and treated with antiparasitic compounds in two forms of tablets (Albendazole, Pyrantel, Ivermectin, Phenasal) and mineral-salt cube (Albenvet, Trimeratinvet). The result of the study showed that began 10, 20, and 30 days after experimentation, the mineral-salt cube significantly reduced the number of helminths and Eimeria spp. in sheep (92.18%) (P≤0.05). Ant antiparasitic drugs in livestock diet are essential in reducing contamination and its effects on the herd.