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Updated: Jul 27, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

493

To Study the Role of PTEN, EGFR and HER2 in Early Glottic Squamous Cell Carcinoma

Sachin Goel1, Ankur Batra2, Gaurang Singhal3

  • 1Department of ENT, ABVIMS & Dr RML Hospital, New Delhi, India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|June 5, 2023
PubMed

Insights

This study investigated PTEN and EGFR in early glottic squamous cell carcinoma. Results suggest PTEN and EGFR may serve as prognostic markers and targets for future laryngeal cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Head and Neck Cancer Research

Background:

  • Laryngeal carcinoma is a prevalent head and neck malignancy with limited surgical options, often managed with chemoradiotherapy.
  • Targeted therapy presents a promising novel approach for treating laryngeal cancer.
  • Understanding molecular markers is crucial for improving treatment strategies.

Purpose of the Study:

  • To evaluate the role of Phosphatase and Tensin homolog (PTEN), Epidermal Growth Factor Receptor (EGFR), and Human Epidermal growth factor Receptor 2 (HER2) in early glottic squamous cell carcinoma.
  • To assess the potential of these molecules as prognostic markers and therapeutic targets.

Main Methods:

  • Histopathologic and immunohistochemical (IHC) examination of 52 early glottic squamous cell carcinoma samples.
  • Analysis of PTEN, EGFR, and HER2 expression in tumor tissues.
  • Correlation of marker expression with three-year local control rates.

Main Results:

  • PTEN was negative in 82.69% of cases, associated with a 72.09% three-year local control rate.
  • EGFR was positive in 67.31% of samples, with a 68.57% three-year local control rate.
  • HER2 expression was negative in all analyzed samples.

Conclusions:

  • PTEN and EGFR expression levels show potential as prognostic indicators in early glottic squamous cell carcinoma.
  • These molecules may represent viable targets for future targeted therapy strategies in laryngeal cancer treatment.
Keywords:
EGFRGlottic carcinomaHER2MicroarrayPTEN

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