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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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A case of cutaneous

Louis J Born1, Shealinna Ge2, Juris P Germanas2,3

  • 1University of Maryland School of Medicine Baltimore Maryland USA.

Skin Health and Disease
|June 5, 2023
PubMed

Insights

Scedosporium apiospermum, a mold, can cause severe infections in immunocompromised individuals. This study details the first reported skin infection in a rheumatoid arthritis patient on a Janus kinase inhibitor, alongside a review of similar cases.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Scedosporium apiospermum is a fungus found in soil and water, occasionally causing opportunistic infections.
  • It poses a risk to immunocompromised patients, potentially leading to severe systemic disease.
  • Hospital-acquired infections are also a concern due to airborne fungal spores.

Purpose of the Study:

  • To report the first case of cutaneous Scedosporium apiospermum infection.
  • To describe this infection in a patient with rheumatoid arthritis treated with a Janus kinase inhibitor.
  • To review cutaneous manifestations of Scedosporium apiospermum from 2003-2022.

Main Methods:

  • Case report of a patient with rheumatoid arthritis and Scedosporium apiospermum skin infection.
  • Literature review of published cutaneous Scedosporium apiospermum cases between 2003 and 2022.

Main Results:

  • A patient with rheumatoid arthritis on Janus kinase inhibitor therapy developed a cutaneous Scedosporium apiospermum infection.
  • The review identified various cutaneous presentations of Scedosporium apiospermum infections.

Conclusions:

  • Cutaneous Scedosporium apiospermum infection is a rare but significant opportunistic infection.
  • Immunocompromised patients, including those on Janus kinase inhibitors, are at risk.
  • Awareness of diverse clinical presentations is crucial for timely diagnosis and treatment.

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