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Pruritus and brain tumours: A prospective and descriptive study
Marie-Anne Fardel1,2, Emilie Brenaut1,2, Dewi Guellec2,3
1Department of Dermatology University Hospital of Brest Brest France.
Background:
Pruritus, especially localised to the nostrils, has been reported as a specific sign of brain tumours.
Objectives:
The main goal of this study was to estimate the prevalence of pruritus in a group of patients with brain tumours. The second outcome was to better characterise this pruritus with a specific questionnaire and a skin examination.
Methods:
From June 2020 to September 2021, all patients with a diagnosis of brain tumour were included in this prospective, monocentric study. If the patient suffered from pruritus, a dermatological examination was performed.
Results:
Two hundred patients with brain tumours were included. Thirty-five of them suffered from pruritus (17.5%). Among them, 15 patients did not present with any skin disease, and 8 could have neuropathic pruritus according to the NP5 questionnaire. No patients presented with pruritus of the nostrils.
Discussion:
This study did not show clear evidence of specifically localised pruritus induced by brain tumours.
Conclusion:
Pruritus observed in patients with brain tumours seems not to be caused by the brain malignancies in most cases. The specific localization to the nostrils cannot be considered a specific marker.
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