The therapeutic mechanism of
Qiang Wu1, Min He2, Jing Wang1
1Agricultural College, Yibin Vocational and Technical College, Yibin, China.
Frontiers in Veterinary Science
|June 5, 2023
Summary
Chebulae Fructus, a traditional Chinese medicine, demonstrates immunosuppressive effects by modulating key targets and pathways. Network analysis and quail experiments reveal its potential for treating immunosuppression.
Area of Science:
- Pharmacology
- Immunology
- Network Medicine
Background:
- Chebulae Fructus (Terminalia chebula Retz.) is a traditional Chinese medicine (TCM) with a history of use.
- Its immature fruit, Fructus Chebulae Immaturus, is also known as Zangqingguo.
- Understanding its therapeutic mechanisms against immunosuppression is crucial.
Purpose of the Study:
- To identify the therapeutic targets and mechanisms of Chebulae Fructus against immunosuppression.
- To validate these findings through network analysis and experimental models.
Main Methods:
- Searched TCM pharmacology databases for Chebulae Fructus components and targets.
- Constructed protein-protein interaction networks and performed enrichment analysis to identify hub genes and pathways.
- Utilized a Chinese yellow quail model for experimental validation.
Main Results:
- Identified 75 candidate targets for Chebulae Fructus, constructing a drug-compound-target-disease network.
- Key pathways involved include lipid metabolism, atherosclerosis, and hepatitis B.
- Animal experiments showed increased lymphoid follicle size and upregulated GATA-3 and T-bet expression.
Conclusions:
- Chebulae Fructus exhibits significant immunosuppressive effects.
- It holds promise for future therapeutic applications in managing immunosuppression.
- Further research is warranted to elucidate detailed mechanisms of action.
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