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Inflammatory microRNAs in cardiovascular pathology: another brick in the wall

Laura Zapata-Martínez1, Sonia Águila1, Ascensión M de Los Reyes-García1

  • 1Department of Hematology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, Universidad de Murcia, IMIB Pascual Parrilla, Murcia, Spain.

Frontiers in Immunology
|June 5, 2023
PubMed

Insights

Specific microRNAs, known as inflamma-miRs, play a key role in regulating inflammation in cardiovascular diseases. Targeting these inflamma-miRs may offer new diagnostic and therapeutic strategies for cardiovascular conditions.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Immunology

Background:

  • MicroRNAs (miRNAs) regulate protein expression and are implicated in various pathophysiological processes.
  • Inflammation is increasingly recognized as a significant cardiovascular risk factor.
  • Specific miRNAs, termed 'inflamma-miRs', are emerging as key regulators of inflammatory status in cardiovascular pathology.

Purpose of the Study:

  • To review the role of inflamma-miRs in cardiovascular diseases.
  • To elucidate the molecular mechanisms by which these miRNAs influence atherogenesis.
  • To discuss the impact of miRNAs on neutrophil extracellular traps in cardiovascular disease.

Main Methods:

  • Literature review of published data on miRNAs and cardiovascular pathology.
  • Analysis of the functional roles of specific inflamma-miRs (miR-21, miR-33, miR-34a, miR-146a, miR-155, miR-223).
  • Focus on molecular mechanisms in atherogenesis and regulation of neutrophil extracellular traps.

Main Results:

  • Identified key inflamma-miRs (miR-21, miR-33, miR-34a, miR-146a, miR-155, miR-223) involved in thromboinflammation.
  • Detailed the functions of these miRNAs in cardiovascular pathologies, particularly atherogenesis.
  • Highlighted the role of miRNAs in regulating neutrophil extracellular traps and their cardiovascular impact.

Conclusions:

  • Inflamma-miRs are critical regulators of inflammatory processes in cardiovascular diseases.
  • Targeting or modulating inflamma-miR levels holds potential for improved diagnosis, prognosis, and treatment of cardiovascular events.
  • Further research into inflamma-miRs could lead to novel therapeutic strategies for inflammatory cardiovascular conditions.
Keywords:
cardiovascular diseasesinflammationmicroRNAsneutrophil extracellular traps (NET)thromboinflammation

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