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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

303
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
303
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

227
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
227
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

364
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
364
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

174
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
174

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Machine learning-based solution reveals cuproptosis features in inflammatory bowel disease.

Le Liu1, Liping Liang2,3, Chenghai Yang1

  • 1Integrated Clinical Microecology Center, Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Frontiers in Immunology
|June 5, 2023
PubMed
Summary

Cuproptosis-related genes (CRGs) like PDHA1, DLD, and FDX1 are linked to immune profiles in inflammatory bowel disease (IBD). These genes show potential as biomarkers and therapeutic targets for IBD.

Keywords:
clustercuproptosisimmune landscapeinflammatory bowel diseasesingle-cell RNA-seq

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Area of Science:

  • Cell Death Mechanisms
  • Immunology
  • Gastroenterology

Background:

  • Cuproptosis, a novel cell death pathway, is influenced by mitochondrial metabolism and protein lipoylation.
  • Cuproptosis-related genes (CRGs) significance in inflammatory bowel disease (IBD) and their immune microenvironment interactions remain underexplored.

Purpose of the Study:

  • To investigate the clinical significance of CRGs in IBD.
  • To explore the relationship between CRGs and the immune microenvironment in IBD.
  • To identify potential diagnostic and therapeutic targets for IBD based on CRGs.

Main Methods:

  • Screening of CRGs correlated with immune status using ssGSEA and GEO datasets.
  • Patient clustering based on CRG expression using CensusClusterPlus.
  • Analysis of gene enrichment, immune cell infiltration, and immune functions via GSEA, GSVA, and CIBERSORT.
  • WGCNA, DEG analysis, and PPI network construction to identify hub genes.
  • External validation using GSE36807 and GSE10616 datasets and scRNA-seq profiling.

Main Results:

  • Three CRGs (PDHA1, DLD, FDX1) significantly correlated with immune profiles in IBD.
  • Two patient clusters identified based on CRG expression patterns.
  • Cluster 2 exhibited enrichment in RNA processes and protein synthesis, with higher immune cell infiltration and immune molecule levels compared to Cluster 1.
  • PPI network analysis revealed key gene modules related to mitochondrial metabolism, cell development, and transport.
  • External validation and scRNA-seq confirmed CRG expression variations in IBD gut tissues.

Conclusions:

  • PDHA1, DLD, and FDX1 are implicated in IBD pathogenesis and exhibit potential as immune biomarkers.
  • These CRGs may serve as novel therapeutic targets for precise IBD diagnosis and treatment.
  • Understanding CRG roles enhances insights into IBD development and management strategies.