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Updated: Jul 27, 2025

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

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Tyrosine kinase inhibitors and human epidermal growth factor receptor-2 positive breast cancer

Aya Abunada1, Zaid Sirhan2, Anita Thyagarajan2

  • 1Department of Pharmacy, Sidra Medicine, Doha 0000, Qatar.

World Journal of Clinical Oncology
|June 5, 2023
PubMed

Insights

Recent advancements in tyrosine kinase inhibitors (TKIs) offer improved outcomes for HER2-positive breast cancer (BC) patients. This commentary reviews key findings on TKI agents and their clinical significance.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Human epidermal growth factor receptor-2 (HER2) positive breast cancer (BC) is a significant clinical challenge.
  • Targeted therapies have revolutionized BC treatment over the last decade.

Purpose of the Study:

  • To review recent findings on tyrosine kinase inhibitors (TKIs) for HER2-positive BC.
  • To highlight the clinical significance of TKIs in improving patient outcomes.

Main Methods:

  • Literature review and commentary.
  • Focus on widely-studied TKI agents.

Main Results:

  • Growing evidence supports the efficacy of HER2-directed therapies.
  • TKIs show particular promise in treating HER2-positive malignancies.
  • Recent findings underscore the clinical importance of TKIs.

Conclusions:

  • TKIs represent a critical advancement in HER2-positive BC treatment.
  • Continued research into TKI agents is vital for optimizing patient outcomes.
Keywords:
Human epidermal growth factor receptor-2 positive breast cancerLapatinibPyrotinibTrastuzumabTucatinibTyrosine kinase inhibitors

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