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Fatma Sm Moawed1, Riham Abdel-Hamid Haroun2, Eman S Abou Zaid2

  • 1Health Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.

International Journal of Immunopathology and Pharmacology
|June 5, 2023
PubMed
Summary

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This study investigated copper-cetyl tri-methyl ammonium bromide with gallium oxide nanoparticles (Cu-CTAB+GaO-NPs) for hepatocellular carcinoma (HCC). Results show Cu-CTAB+GaO-NPs exhibit significant cytotoxic and antiproliferative effects against HCC in vitro and in vivo.

Area of Science:

  • Biomedical Science
  • Nanotechnology
  • Oncology

Background:

  • Hepatocellular carcinoma (HCC) is a leading global cause of cancer death.
  • Gallium and cetyltrimethylammonium bromide (CTAB) have demonstrated antineoplastic properties.
  • Novel nanoparticle formulations are needed for effective HCC treatment.

Purpose of the Study:

  • To evaluate the efficacy of copper-cetyl tri-methyl ammonium bromide with gallium oxide nanoparticles (Cu-CTAB+GaO-NPs) against HCC.
  • To assess the in vitro cytotoxic effects of Cu-CTAB+GaO-NPs and gallium oxide nanoparticles (GaO-NPs) on HepG-2 cells.
  • To investigate the in vivo therapeutic potential of Cu-CTAB+GaO-NPs in a diethyl nitrosamine (DEN)-induced HCC rat model.

Main Methods:

  • In vitro cytotoxicity assessed using crystal violet dye assay on HepG-2 cell lines.
Keywords:
Cetrimonium bromideDiethyl nitrosamineGallium oxide nanoparticlesHepatocellular carcinomaNanomedicineNanoparticles

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  • In vivo study involved DEN-induced HCC in Wister rats, divided into eight treatment groups.
  • Histopathological examination and biochemical analyses (liver function, oxidative stress, tumor markers, apoptosis) were performed.

    • Main Results:

    • Cu-CTAB+GaO-NPs demonstrated potent cytotoxicity against HepG-2 cells with an IC50 of 0.2 μg/ml.
    • In vivo, Cu-CTAB+GaO-NPs showed significant antiproliferative effects, improving liver tissue recovery.
    • Biochemical markers indicated reduced liver damage and tumor progression, with enhanced antioxidant and apoptosis markers.

    Conclusions:

    • Cu-CTAB+GaO-NPs exhibit significant cytotoxic and antiproliferative activities against HCC.
    • The findings suggest a potential therapeutic role for Cu-CTAB+GaO-NPs in managing HCC.
    • Further research into this novel nanoparticle compound for HCC treatment is warranted.