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Microfluidic systems for particle capture and release: A review.

Liyuan Gong¹, Andrew Cretella¹, Yang Lin¹

¹Department of Mechanical, Industrial and Systems Engineering, University of Rhode Island, Kingston, RI, 02881, USA.

Biosensors & Bioelectronics

|June 5, 2023

Summary

Microfluidic devices excel at capturing and releasing cells and particles. This review highlights the critical importance of efficient release mechanisms for high-throughput analysis, addressing a gap in current research.

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Area of Science:

Biotechnology
Analytical Chemistry
Microfluidics

Background:

Microfluidic devices offer advantages like label-free detection and minimal reagent use for capturing cells, biomolecules, and particles.
Traditional research has focused on capture efficiency, often overlooking the crucial aspect of particle release for subsequent analysis.
Effective particle release is essential for enabling high-throughput analysis in microfluidic systems.

Purpose of the Study:

To emphasize the significance of both capture and release mechanisms in microfluidic systems.
To review and assess the effectiveness of various microfluidic capture-and-release methods.
To summarize recent applications and discuss future directions in microfluidic particle manipulation.

Main Methods:

Keywords:

Environmental particles Microfluidics Microorganisms Particle capture Particle release Single-cell

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Classification of methods into physical principle-based and biochemical approaches.

Comprehensive review of recent microfluidic platforms designed for particle capture and release.

Analysis of device designs, performance, advantages, and limitations across different applications.

Main Results:

Microfluidic capture-and-release platforms provide contactless, label-free, accurate, and sensitive analysis with minimal reagents.
The efficiency of particle release has been a historically overlooked but critical factor for high-throughput microfluidic applications.
Various physical and biochemical methods exist for particle manipulation, each with specific performance characteristics.

Conclusions:

Effective particle release is as vital as capture for advancing microfluidic applications.
Further research is needed to overcome current challenges and optimize release strategies.
Future directions involve developing innovative methods to enhance both capture and release efficiencies for broader applications.