Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

4.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.3K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

169
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
169
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

117
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
117
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

8.7K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study.

Physiological reports·2026
Same author

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses.

npj drug discovery·2026
Same author

Novel 1‑Phenyl-2,3-dihydroquinazolin-4(1H)-one Derivatives as Na<sub>v</sub> 1.8 Voltage-Gated Sodium Channels Inhibitors.

ACS medicinal chemistry letters·2026
Same author

Novel Pyrido[4,3‑<i>d</i>]pyrimidine Derivatives as Kirsten Rat Sarcoma (KRAS) G12C Potential Inhibitors.

ACS medicinal chemistry letters·2026
Same author

Novel Macrocyclic Compounds Targeting STING for Autoimmune Diseases Treatment.

ACS medicinal chemistry letters·2026
Same author

Novel Substituted Tetrahydropyrrolooxazolones as RIPK1 Inhibitors.

ACS medicinal chemistry letters·2026
Same journal

Chlorinated VSLSs Surpass HCFCs in CFC-11-Equivalent Emissions for Ozone Layer Depletion in China.

Nature communications·2026
Same journal

Author Correction: Charge transfer in triphenylamine-tetrazine covalent organic frameworks for solar-driven hydrogen peroxide production.

Nature communications·2026
Same journal

Vegetation browning patterns under compound soil and atmospheric dryness in northern permafrost ecosystems.

Nature communications·2026
Same journal

Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.

Nature communications·2026
Same journal

Radical-omics reveals the hydrogen-abstraction pathway of isoprene oxidation.

Nature communications·2026
Same journal

Toughening elastomer via sequentially activated multi-pathway energy dissipation.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jul 27, 2025

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.6K

Radiochemistry for positron emission tomography.

Jian Rong1,2, Achi Haider1,2, Troels E Jeppesen2

  • 1Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA.

Nature Communications
|June 5, 2023
PubMed
Summary
This summary is machine-generated.

This review overviews radiochemistry methods for creating positron emission tomography (PET) tracers. It highlights advances and challenges in developing new PET imaging agents for disease diagnosis and drug development.

More Related Videos

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

11.3K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

483

Related Experiment Videos

Last Updated: Jul 27, 2025

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.6K
Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

11.3K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

483

Area of Science:

  • Radiochemistry
  • Molecular Imaging
  • Nuclear Medicine

Background:

  • Positron emission tomography (PET) is a functional imaging technique used in vivo.
  • PET aids in disease diagnosis, progression monitoring, and drug development.
  • The growing applications of PET necessitate advancements in radiochemistry for novel tracer synthesis.

Purpose of the Study:

  • To provide an overview of chemical transformations for PET tracer synthesis.
  • To highlight recent breakthroughs and challenges in radiochemistry for PET.
  • To discuss the use of biologicals and scalable radiochemistry in PET imaging.

Main Methods:

  • Literature review of radiochemistry techniques for PET tracer synthesis.
  • Analysis of commonly used chemical transformations.
  • Discussion of biologicals and translational radiochemistry concepts.

Main Results:

  • Overview of established and emerging radiochemistry methods for PET.
  • Identification of key challenges and recent discoveries in the field.
  • Examples of successful PET probe development, including clinical applications.

Conclusions:

  • Advancements in radiochemistry are crucial for expanding PET imaging capabilities.
  • Translational and scalable radiochemistry are key for clinical translation of PET tracers.
  • Continued innovation is needed to address contemporary challenges in PET tracer development.