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Updated: Jul 27, 2025

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Published on: July 30, 2014

The multiple links between actin and mitochondria.

Tak Shun Fung^1,2, Rajarshi Chakrabarti^1,3, Henry N Higgs⁴

¹Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.

Nature Reviews. Molecular Cell Biology

|June 5, 2023

Summary

This summary is machine-generated.

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Actin has diverse roles in mitochondria, influencing fission, shape, glycolysis, mitophagy, and motility. This review highlights actin

Area of Science:

Cell Biology
Mitochondrial Biology
Cytoskeletal Dynamics

Background:

Actin's cellular functions are complex due to overlapping structures.
Mitochondrial biology presents unique challenges for studying actin's roles.
Actin's involvement in mitochondria is increasingly recognized.

Purpose of the Study:

To review the multifaceted roles of actin in mitochondrial biology.
To elucidate actin's distinct functions beyond mitochondrial fission.
To highlight actin's dynamic regulation of mitochondrial processes.

Main Methods:

Literature review of actin's involvement in mitochondrial dynamics.
Analysis of actin polymerization mechanisms (formins, Arp2/3 complex).
Examination of actin's influence on mitochondrial fission, shape, and motility.

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Last Updated: Jul 27, 2025

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

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Visualizing Actin and Microtubule Coupling Dynamics In Vitro by Total Internal Reflection Fluorescence TIRF Microscopy

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Published on: July 20, 2022

Main Results:

Actin polymerization via INF2 regulates mitochondrial fission.
Arp2/3 complex-mediated actin assembly impacts mitochondrial fission.
Actin assembly suppresses shape changes and stimulates glycolysis post-dysfunction.
Later actin polymerization prepares mitochondria for mitophagy.
Actin influences mitochondrial motility, both stimulating and inhibiting it.

Conclusions:

Actin plays multiple, distinct roles in mitochondrial biology.
Actin dynamics are crucial for mitochondrial fission, quality control, and movement.
Understanding these roles is key to comprehending mitochondrial function and cellular health.