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[Particularities and problems of psychopharmacology in childhood and adolescence]
Manfred Gerlach1,2, Tobias Renner3,4, Marcel Romanos5,4
1Klinik und für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie Zentrum für Psychische Gesundheit, Universitätsklinik Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Deutschland. manfred.gerlach@uni-wuerzburg.de.
Abstract:
The drug treatment of mental illness in childhood and adolescence poses a particular clinical and legal challenge. Reasons for this include the often necessary off-label use and existing knowledge gaps regarding the long-term effects of the neuro-/psychotropic drugs used. In this article, the prerequisites for therapy with neuro/psychotropic drugs, such as the need for age-appropriate inclusion of children and adolescents in the decision-making and education process, as well as the evaluation of medication, the consideration of biological age- and maturation-related factors, and the special measures for off-label use, are discussed. We further discuss general problems in the development and use of neuro-/psychotropic drugs, such as the difficulties in relation to proof of effectiveness, reimbursement and liability issues of off-label administration, and the problems of conducting clinical trials with children and adolescents.
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