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Updated: Jul 27, 2025

Author Spotlight: Understanding Cytokine-Induced Cell Death in Intestinal Epithelial Cells Using Human Organoids
Published on: August 2, 2024
Non-lethal outcomes of engaging regulated cell death pathways in cancer
Halime Kalkavan1,2,3, Sebastian Rühl1,4, Jeremy J P Shaw1
1Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Abstract:
Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the engagement of RCD pathways does not inevitably result in cell death. Instead, RCD pathways can take part in diverse biological processes if the cells survive. Consequently, these surviving cells, for which we propose the term 'flatliners', harbor important functions. These evolutionarily conserved responses can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.
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