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HLA-B*27 is associated with CNO in a European cohort

Daire O'Leary1,2, Dalila Ali Al Julandani3, Muhammad Zia4

  • 1Centre for Arthritis Research, Conway Institute, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. daire.oleary@ucdconnect.ie.

Pediatric Rheumatology Online Journal
|June 5, 2023
PubMed
Abstract

Insights

The human leukocyte antigen B27 (HLA-B27) gene is linked to an increased risk of developing chronic nonbacterial osteomyelitis (CNO). This association is particularly pronounced in male patients diagnosed with CNO.

Area of Science:

  • Immunogenetics
  • Rheumatology
  • Pediatric diseases

Background:

  • Chronic nonbacterial osteomyelitis (CNO) is a rare inflammatory bone disease.
  • The genetic factors influencing CNO susceptibility are not fully understood.
  • Human leukocyte antigen B27 (HLA-B27) is a well-known genetic marker associated with several autoimmune and inflammatory conditions.

Approach:

  • This study investigated the association between HLA-B27 positivity and the risk of developing CNO.
  • The research included three European CNO patient cohorts and compared them with large control populations.
  • Genotyping for HLA-B27 was performed using advanced molecular techniques, and imaging (MRI) was utilized to confirm diagnoses and monitor disease progression.

Key Points:

  • A significantly higher frequency of HLA-B27 was observed in CNO patients compared to controls across all cohorts.
  • The association between HLA-B27 and CNO was notably stronger in males than in females.
  • No statistically significant link was found between HLA-B27 status and the presence of co-occurring psoriasis, arthritis, or inflammatory bowel disease.

Conclusions:

  • HLA-B27 carriage is a significant risk factor for developing chronic nonbacterial osteomyelitis.
  • The genetic predisposition to CNO, influenced by HLA-B27, appears to be more pronounced in males.
  • Further research may elucidate the specific mechanisms by which HLA-B27 contributes to CNO pathogenesis.
Keywords:
CNOCRMOChronic nonbacterial osteomyelitisHLAPaediatric rheumatology

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