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A quality assurance measure for pediatric pharmacotherapy showed a trend toward reducing hospitalizations but did not reach statistical significance. The PaedPharm intervention was broadly accepted in outpatient pediatric settings.

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Area of Science:

  • Pediatric pharmacotherapy
  • Drug safety and quality assurance
  • Health services research

Background:

  • Children often receive off-label drug treatments, increasing their risk in pharmacotherapy.
  • Medication-related hospitalizations are a significant concern in pediatric and adolescent medicine.

Purpose of the Study:

  • To implement and evaluate the PaedPharm quality assurance measure for pediatric pharmacotherapy.
  • To reduce medication-related hospitalizations among children and adolescents.

Main Methods:

  • A cluster-randomized trial (DRKS 00013924) involving 12 regions and 152 practitioners.
  • PaedPharm included a digital drug information system (PaedAMIS), quality circles (PaedZirk), and an adverse drug event (ADE) reporting system (PaedReport).
  • Primary endpoint was ADE-related hospital admissions; process evaluation included user acceptance and practice relevance.

Main Results:

  • 41,829 inpatient admissions were analyzed; 5,101 were from participating physicians.
  • ADE-related hospital admissions decreased from 4.1% (control) to 3.1% (intervention), though not statistically significant (p = 0.33).
  • PaedAMIS showed moderate user acceptance, while PaedZirk achieved high user acceptance.

Conclusions:

  • The PaedPharm intervention was associated with a non-significant decrease in medication-related hospitalizations.
  • Broad acceptance of the PaedPharm intervention was observed in outpatient pediatrics and adolescent medicine settings.