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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Related Experiment Video

Updated: Jul 27, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Patient-derived preclinical models to develop immunotherapies.

Joan Seoane1

  • 1Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, ICREA, CIBERONC, Spain.

Molecular Oncology
|June 6, 2023
PubMed
Summary

Patient-derived models are essential for understanding cancer immunotherapy and improving treatments. These models help study the tumor immune microenvironment and advance immuno-oncology research.

Keywords:
immuno-oncologyimmunotherapypatient-derived modelspreclinical modelstranslational modelstumor microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Translational Medicine

Background:

  • Cancer immunotherapy has transformed cancer treatment but faces challenges with non-responsive tumors.
  • Understanding the tumor immune microenvironment is critical for advancing immuno-oncology.
  • Novel therapeutic targets are needed to improve patient outcomes.

Purpose of the Study:

  • To review patient-derived models for cancer immunotherapy research.
  • To highlight the importance of studying the human tumor immune microenvironment.
  • To emphasize the role of patient-derived models in advancing immuno-oncology.

Main Methods:

  • Review of existing literature on patient-derived models.
  • Discussion of platforms for analyzing the tumor immune microenvironment.
  • Exploration of the application of these models in preclinical studies.

Main Results:

  • Patient-derived models offer a platform to study cancer immunity.
  • These models capture tumor immune ecosystem complexity and heterogeneity.
  • They are crucial for understanding treatment mechanisms and improving clinical success.

Conclusions:

  • Patient-derived models are fundamental for advancing cancer immunotherapy.
  • Further research using these models will identify new therapeutic targets.
  • Improved preclinical studies with patient-derived models can enhance clinical trial success.