B(C

Area of Science:

• Organic Chemistry
• Catalysis
• Synthetic Methodology

Background:

• Thiosulfonylation reactions are crucial for synthesizing sulfur-containing organic compounds.
• Developing metal-free catalytic systems is a key goal in green chemistry.

Purpose of the Study:

• To establish a metal-free main-group catalysis system for the thiosulfonylation of terminal alkynes.
• To develop a highly regio- and stereoselective synthetic route for (E)-(β)-arylthiolvinyl sulfones.

Main Methods:

• Utilized commercially available B(C6F5)3 as a catalyst.
• Employed terminal alkynes and thiosulfonates as starting materials.
• Optimized reaction conditions for mildness and efficiency.

Main Results:

• Achieved a novel metal-free catalysis system for thiosulfonylation.
• Synthesized diverse (E)-(β)-arylthiolvinyl sulfones with high regio- and stereoselectivity.
• Demonstrated 100% atom-economy and exceptional functional group compatibility.

Conclusions:

• The developed protocol offers an efficient, selective, and environmentally friendly method for synthesizing vinyl sulfones.
• This metal-free approach expands the toolkit for constructing complex sulfur-containing molecules.