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Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

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Published on: February 25, 2021

Lipid nanoparticle-based formulations for high-performance dentistry applications.

Isha Mutreja¹, Dhiraj Kumar², Ajeet Kaushik³

¹Minnesota Dental Research Center for Biomaterials and Biomechanics, Department of Restorative Sciences, University of Minnesota, Moos Health Science Tower, 515 Delaware Street S.E., Minneapolis, MN 55455, USA. imutreja@umn.edu.

Journal of Materials Chemistry. B

|June 6, 2023

Summary

Nanolipids show promise as affordable, biologically acceptable antibacterial nanostructures for dental care. This review bridges the knowledge gap for their clinical translation and FDA approval in dentistry.

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Area of Science:

Biomaterials science
Nanotechnology
Dental research

Background:

Growing need for novel, high-performance, and affordable biomaterials in dentistry to combat oral diseases.
Challenges with existing dental materials include cytotoxicity and limited clinical acceptance.
Nanolipids offer a promising avenue for next-generation dental therapeutics.

Purpose of the Study:

To address the knowledge gap in developing and translating nanolipid formulations for dental applications.
To critically review literature for selecting appropriate nanolipid systems for targeted dental issues.
To discuss the future of nanolipids in dentistry, focusing on clinical adaptability, risks, and regulatory pathways.

Main Methods:

Comprehensive literature review and critical analysis of existing research on nanolipids in dentistry.
Evaluation of nanolipid properties, formulation strategies, and pharmacological potential.
Exploration of challenges and alternative approaches for clinical translation and FDA approval.

Main Results:

Nanolipids can be designed as programmable systems with tunable responsiveness for targeted disease management.
Identification of key considerations for selecting nanolipid systems based on specific dental conditions.
Summary of the current state of research, highlighting areas needing further investigation.

Conclusions:

Nanolipids represent a significant advancement for developing advanced dental care solutions.
Systematic research and addressing potential risks are crucial for successful clinical translation and FDA approval.
Further studies focusing on clinical adaptability will pave the way for nanolipid integration into routine dental practice.