Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

5.6K
Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
5.6K
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction01:26

Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

3.4K
α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
3.4K
Dehydration Synthesis01:15

Dehydration Synthesis

133.7K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
133.7K
Synthetic Biology02:55

Synthetic Biology

4.9K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.9K
Transcription01:10

Transcription

147.3K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
147.3K
Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

3.6K
Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ag(I)-mediated <i>mono</i>-selective C(sp<sup>2</sup>)-H chalcogenation of α-aminotropones and their peptides at room temperature.

Chemical communications (Cambridge, England)·2025
Same author

DNA-Based Ultrasensitive Cu(II) Sensor: Troponyl-Thymidine Oligo (T*<sub>4</sub>T) Forms Copper-Mediated Duplex Structure.

Chembiochem : a European journal of chemical biology·2025
Same author

Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer.

Cancer cell international·2025
Same author

Clinical outcome of treatment intensification in type 2 diabetes mellitus patients with suboptimal glycemic control on two oral antidiabetic agents.

Journal of family medicine and primary care·2025
Same author

Tropone-Enabled Pd-Catalyzed C(sp<sup>2</sup>)-H Functionalization of Phenylalanine: Switchable Access to Indoline and Olefinate.

Organic letters·2025
Same author

Gray-Scale Ultrasonography of Lung and Sonoelastography of the Diaphragm in Interstitial Lung Disease With HRCT Association.

Ultrasound quarterly·2025

Related Experiment Video

Updated: Jul 27, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
12:30

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

9.1K

Synthesis of

Manish K Gupta1,2, Ankita Panda1,2, Subhasish Panda1,2

  • 1School of Chemical Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, Jatani-752050, Odisha, India. nagendra@niser.ac.in.

Organic & Biomolecular Chemistry
|June 6, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to synthesize isoindolinone-containing peptides, enabling exploration of their structure and potential as therapeutic agents and novel foldamers.

More Related Videos

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

19.1K
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

10.8K

Related Experiment Videos

Last Updated: Jul 27, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
12:30

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

9.1K
Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

19.1K
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

10.8K

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Biochemistry

Background:

  • Isoindolinone is a core structure in natural products with diverse bioactivities including anticancer, antimicrobial, antiviral, and anti-inflammatory properties.
  • Exploring the isoindolinone scaffold's carbonyl group (H-bond acceptor) and its impact on molecular conformation is of significant interest.
  • Synthesizing peptides incorporating the isoindolinone moiety efficiently remains a synthetic challenge.

Purpose of the Study:

  • To develop a streamlined synthetic strategy for incorporating isoindolinone into peptide structures.
  • To investigate the conformational alterations induced by the isoindolinone scaffold within peptides.
  • To establish isoindolinonyl peptides as a platform for novel foldamer and therapeutic agent development.

Main Methods:

  • Utilized palladium-catalyzed C(sp2)-H activation/olefination for efficient isoindolinone residue introduction into peptides.
  • Employed synthetic chemistry techniques to construct novel isoindolinonyl peptides.

Main Results:

  • Successfully developed a novel synthetic methodology for peptide-isoindolinone conjugation.
  • Demonstrated significant conformational changes in peptides due to the presence of the isoindolinone scaffold.
  • Confirmed the feasibility of synthesizing complex isoindolinonyl peptides.

Conclusions:

  • The developed Pd-catalyzed method offers a facile route to isoindolinonyl peptides.
  • Isoindolinonyl peptides exhibit unique conformational properties, distinct from traditional peptides.
  • This work opens new possibilities for designing advanced foldamers and novel therapeutic agents.