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Related Experiment Video

Updated: Jul 27, 2025

Design, Fabrication, and Administration of the Hand Active Sensation Test HASTe
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H

Shaohu Huo1,2, Qianhui Xie3, Min Zhang1

  • 1Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.

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|June 6, 2023
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Summary
This summary is machine-generated.

This study developed Gm@UiO-66-MA, a novel material that eliminates hydrogen sulfide (H2S) to resensitize bacteria to antibiotics. This approach enhances antibiotic effectiveness against tolerant bacteria and promotes wound healing.

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Area of Science:

  • Materials Science
  • Antimicrobial Research
  • Nanotechnology

Background:

  • Antibiotic tolerance contributes to challenging infections and the rise of antibiotic resistance.
  • Hydrogen sulfide (H2S) is linked to intrinsic bacterial resistance to antibiotics.
  • Metal-organic frameworks (MOFs), like UiO-66, show promise for drug delivery due to their properties.

Purpose of the Study:

  • To design and fabricate an antibiotic sensitizer to combat antibiotic tolerance.
  • To eliminate bacterial endogenous H2S using a modified MOF.
  • To enhance the efficacy of existing antibiotics against tolerant bacterial strains.

Main Methods:

  • Fabrication of Gm@UiO-66-MA by modifying UiO-66-NH2 with maleic anhydride (MA) and loading with gentamicin (Gm).
  • Demonstration of UiO-66-MA's ability to remove bacterial H2S via Michael addition.
  • Assessment of Gm@UiO-66-MA's efficacy in reducing H2S levels and enhancing antibiotic susceptibility in tolerant *E. coli*.
  • In vivo evaluation in a skin wound healing model.

Main Results:

  • Gm@UiO-66-MA effectively removed bacterial H2S and disrupted bacterial biofilms.
  • The material significantly enhanced the susceptibility of H2S-tolerant *E. coli* to gentamicin.
  • In vivo studies showed reduced bacterial reinfection and accelerated wound healing with Gm@UiO-66-MA treatment.

Conclusions:

  • Gm@UiO-66-MA acts as a potent antibiotic sensitizer by targeting bacterial H2S.
  • This strategy offers a promising therapeutic approach for refractory infections caused by antibiotic-tolerant bacteria.
  • The developed MOF-based material holds potential for minimizing the development and spread of antibiotic resistance.