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Updated: Jul 27, 2025
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Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium
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Electrochemical Approach for the Synthesis of Ultrasmall Cu
Teena Thomas1, Haritha Kuttoth1, Resmi V Nair1
1Nanoscience Research Laboratory, School of Materials Science and Engineering, National Institute of Technology Calicut, Calicut 673601, Kerala, India.
Langmuir : the ACS Journal of Surfaces and Colloids
|June 6, 2023
Summary
Blue-emitting copper nanoclusters detect bacterial endotoxins with high sensitivity. This electrochemical sensor offers a low detection limit for endotoxin analysis in human blood serum.
Area of Science:
- Nanotechnology
- Electrochemistry
- Analytical Chemistry
Background:
- Ultrasmall metal nanoclusters exhibit unique size-dependent optical and electrochemical properties.
- Copper nanoclusters are promising for various applications due to their tunable characteristics.
Purpose of the Study:
- To synthesize blue-emitting copper nanoclusters using an electrochemical method.
- To develop an electrochemical sensor for sensitive and selective endotoxin detection.
Main Methods:
- Electrochemical synthesis of copper nanoclusters stabilized with CTAB.
- Electrospray ionization (ESI) for cluster characterization (13 copper atoms).
- Differential pulse voltammetry (DPV) for endotoxin detection.
Main Results:
- Successfully synthesized blue-emitting copper nanoclusters.
- ESI confirmed a 13-atom copper core.
- DPV demonstrated high selectivity and sensitivity for endotoxin detection.
- Achieved a low detection limit of 100 ag mL-1 with a linear range up to 10 ng mL-1.
Conclusions:
- The developed copper nanocluster-based sensor is efficient for detecting bacterial endotoxins.
- The sensor shows promise for analyzing endotoxins in complex biological matrices like human blood serum.
