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Asterosaponins from the starfish

Le Thi Vien1, Tran Thi Hong Hanh1, Tran Hong Quang1

  • 1Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi 10072, Vietnam.

Journal of Asian Natural Products Research
|June 6, 2023
PubMed
Summary

Starfish Protoreaster nodosus yielded five asterosaponins, including a new compound, protonodososide. These compounds were tested for their potential to fight various human cancer cell lines.

Keywords:
AsteroideaProtoreaster nodosusasterosaponinscytotoxic activityprotonodososide

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Area of Science:

  • Marine Natural Products Chemistry
  • Pharmacology

Background:

  • Starfish are a rich source of bioactive compounds.
  • Asterosaponins are a class of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize asterosaponins from Protoreaster nodosus.
  • To evaluate the cytotoxic effects of isolated compounds against human cancer cell lines.

Main Methods:

  • Methanol extraction of starfish.
  • Chromatographic separation techniques.
  • 1D, 2D NMR, and HR ESI QTOF mass spectrometry for structural elucidation.
  • Cytotoxicity assays on HepG2, KB, MCF7, LNCaP, and SK-Mel2 cell lines.

Main Results:

  • Five asterosaponins were isolated, with one identified as a new compound, protonodososide.
  • The structures of all isolated compounds were confirmed through spectroscopic analysis.
  • Cytotoxicity data was obtained for all compounds against the tested cancer cell lines.

Conclusions:

  • Protoreaster nodosus is a source of novel asterosaponins.
  • The isolated asterosaponins exhibit varying degrees of cytotoxicity against human cancer cell lines, warranting further investigation.