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Neuropathologic correlates of cerebral microbleeds in community-based older adults

Grant Nikseresht1, Arnold M Evia2, Sukriti Nag2

  • 1Department of Computer Science, Illinois Institute of Technology, Chicago, IL, USA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.

Neurobiology of Aging
|June 6, 2023
PubMed

Insights

Cerebral microbleeds (CMBs) in older adults are linked to small vessel diseases like cerebral amyloid angiopathy. However, these small hemorrhages were not associated with dementia in this study.

Area of Science:

  • Neurology
  • Neuroimaging
  • Pathology

Background:

  • Cerebral microbleeds (CMBs) are associated with cognitive decline and mortality.
  • Neuropathologic correlates of CMBs in community-dwelling older adults remain unclear.

Purpose of the Study:

  • To investigate the association between age-related neuropathologies and CMBs in community-dwelling older adults.

Main Methods:

  • Ex vivo MRI and detailed neuropathologic examination of cerebral hemispheres from 289 participants.
  • Analysis included participants from multiple longitudinal aging studies.

Main Results:

  • CMBs were associated with cerebral amyloid angiopathy (overall and frontal lobe).
  • Frontal lobe CMBs were also linked to arteriolosclerosis.
  • Basal ganglia CMBs showed a borderline association with microinfarcts.
  • CMBs were not associated with dementia.

Conclusions:

  • CMBs may help predict small vessel disease in older adults.
  • CMBs in community-dwelling older adults may not indicate substantial cognitive impairment.
Keywords:
BiomarkersEx vivoMagnetic resonance imagingMicrobleedNeuropathology

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