Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Surgical Fixation Enhances Discharge Independence in Elderly Patients With Fragility Fractures of the Pelvis.

Journal of orthopaedic trauma·2026

Same author

Robotic Assistance in Posterolateral Lumbar Fusion Is Associated with Higher Comorbidity Burden, Greater 90-Day Infectious Complications, and Increased Episode Costs.

The spine journal : official journal of the North American Spine Society·2026

Same author

Non-Tobacco Nicotine Is Associated With Increased Complications Following Posterior Cervical Fusion: A Retrospective Cohort Study.

Global spine journal·2026

Same author

The AO Spine Upper Cervical Injury Score (UCIS): Development of a Consensus-Based Scoring System Based on Perceived Injury Severity Scores.

Global spine journal·2026

Same author

Anterior Lumbar Interbody Fusion Offers Safer Inpatient Profiles But at Greater Cost Compared With Posterolateral Fusion: National Outcomes for Spondylolisthesis From 2016 to 2022.

The Journal of the American Academy of Orthopaedic Surgeons·2026

Same author

The efficacy of ChatGPT as a student resource for the diagnosis and treatment of neck pain.

Disability and rehabilitation·2026

Same journal

Patient Satisfaction and Outcomes at a Mean 11-Year Follow-Up Following Total Hip Arthroplasty with Subtrochanteric Osteotomy for Dislocated Hips After Schanz Osteotomy.

The Journal of arthroplasty·2026

Same journal

Comparative Analysis of Periprosthetic Joint Infection Rates After Total Hip Arthroplasty Across Facility Types: A Single Institution Study.

The Journal of arthroplasty·2026

Same journal

Preoperative Pneumonia and Its Association With Periprosthetic Joint Infection and Postoperative Complications After Total Hip and Knee Arthroplasty.

The Journal of arthroplasty·2026

Same journal

Conversion Total Hip Arthroplasty Following Prior Internal Fixation: A Comparison with Primary and Revision Total Hip Arthroplasty.

The Journal of arthroplasty·2026

Same journal

The Relationship Between Patient Satisfaction and the Degree of Valgus Deformity in Lateral Unicompartmental Knee Arthroplasty at a Mean 3-Year Follow-Up.

The Journal of arthroplasty·2026

Same journal

Kneeling After Total Knee Arthroplasty: Does Resurfacing the Patella Affect the Ability to Kneel?

The Journal of arthroplasty·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 27, 2025

Knee Arthrocentesis in Adults

Knee Arthrocentesis in Adults

Published on: February 25, 2022

Does Semaglutide Use Decrease Complications and Costs Following Total Knee Arthroplasty?

Matthew L Magruder¹, Vincent J H Yao², Ariel N Rodriguez¹

¹Department of Orthopaedic Surgery, Maimonidies Medical Center, Brooklyn, New York.

The Journal of Arthroplasty

|June 6, 2023

Summary

This summary is machine-generated.

Semaglutide use in total knee arthroplasty (TKA) patients with diabetes showed reduced sepsis, infection, and readmission risks. However, it also increased risks for myocardial infarction, kidney injury, pneumonia, and hypoglycemia.

Keywords:

complications diabetes mellitus prosthetic joint infections semaglutide sepsis total knee arthroplasty

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

Related Experiment Videos

Last Updated: Jul 27, 2025

Knee Arthrocentesis in Adults

Knee Arthrocentesis in Adults

Published on: February 25, 2022

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

Area of Science:

Orthopedic Surgery
Endocrinology
Pharmacology

Background:

Diabetes mellitus (DM) and obesity are known risk factors for complications following total knee arthroplasty (TKA).
Semaglutide, a medication used for DM and weight management, may influence TKA outcomes.

Purpose of the Study:

To investigate the impact of semaglutide use on medical and implant-related complications after TKA.
To evaluate the effect of semaglutide on readmission rates and costs in TKA patients.

Main Methods:

A retrospective analysis of a national database (up to 2021) was conducted.
Patients with osteoarthritis undergoing TKA, with DM and semaglutide use, were propensity score-matched to a control group (n=7,051 vs. 34,524).
Outcomes assessed included 90-day medical complications, 2-year implant complications, 90-day readmissions, length of stay, and costs, analyzed using multivariate logistic regression.

Main Results:

Semaglutide use was associated with increased odds of myocardial infarction, acute kidney injury, pneumonia, and hypoglycemia.
Conversely, semaglutide cohorts demonstrated lower odds of sepsis, prosthetic joint infections, and 90-day readmissions.
A trend towards lower revision rates and reduced 90-day costs was observed in the semaglutide group.

Conclusions:

Semaglutide use in TKA patients with DM is linked to a decreased risk of sepsis, prosthetic joint infections, and readmissions.
However, semaglutide use also elevates the risk of specific medical complications, including myocardial infarction, acute kidney injury, pneumonia, and hypoglycemia.