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Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
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Updated: Jul 27, 2025

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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Developmental differences in functional organization of multispectral networks.

Nathan M Petro1,2, Giorgia Picci1,2,3, Christine M Embury1,2

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|June 6, 2023
PubMed
Summary
This summary is machine-generated.

Brain connectivity in youth (9-15 years) becomes more segregated with age, particularly in delta and alpha frequency bands, as measured by magnetoencephalography (MEG). This developmental shift impacts limbic and cognitive networks.

Keywords:
adolescenceconnectivitymagnetoencephalographyoscillationresting statespontaneous

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Brain Imaging

Background:

  • Resting-state brain connectivity assessment is crucial for understanding developmental changes in functional brain organization.
  • Previous research, primarily using fMRI, indicates a shift from local to distributed processing during development.
  • Multispectral functional connectivity using magnetoencephalography (MEG) remains less characterized in this context.

Purpose of the Study:

  • To investigate developmental changes in multispectral functional connectivity using MEG during rest in typically developing youth.
  • To characterize age-related alterations in brain network organization across different frequency bands.

Main Methods:

  • Examined spontaneous cortical activity during eyes-closed rest in 101 typically developing youth (9-15 years) using MEG.
  • Computed multispectral MEG images and estimated functional connectivity using the imaginary part of the phase coherence between 200 brain regions (Schaefer cortical atlas).
  • Analyzed connectivity in delta, theta, alpha, beta, and gamma frequency bands.

Main Results:

  • Delta and alpha connectivity matrices showed increased community structure with age.
  • Connectivity weights generally decreased with age across both delta and alpha bands.
  • Delta band differences were associated with limbic cortical regions; alpha band differences involved attention and cognitive networks.

Conclusions:

  • Brain functional organization becomes more segregated during development in youth, consistent with prior research.
  • Developmental changes in brain connectivity exhibit spectral specificity across canonical brain networks.
  • MEG-based multispectral analysis provides valuable insights into neurodevelopmental changes in brain organization.