Association between metabolic syndrome and stroke: a population based cohort study

Area of Science:

• Epidemiology
• Cardiovascular Health
• Metabolic Disorders

Background:

• Metabolic syndrome (MetS) and stroke are significant contributors to mortality.
• Understanding the prevalence of MetS and its association with stroke is vital for public health.

Purpose of the Study:

• To determine the prevalence of MetS in Iranian adults using three distinct definitions.
• To investigate the association between MetS and the risk of stroke.

Main Methods:

• A cross-sectional study involving 9991 adults from the Rafsanjan Cohort Study (PERSIAN cohort).
• Prevalence assessment using Adult Treatment Panel III (ATP-III), International Diabetes Federation (IDF), and Iranian IDF criteria.
• Multivariate logistic regression and ROC curve analysis to assess the association with stroke.

Main Results:

• MetS was significantly associated with increased odds of stroke across all three definitions (ATP-III, IDF, Iranian IDF).
• Odds ratios ranged from 1.48 to 1.89 after adjusting for confounders.
• Receiver operating characteristic (ROC) curve analysis indicated moderate accuracy in identifying increased stroke risk for all MetS criteria.

Conclusions:

• Metabolic syndrome is a significant risk factor for stroke.
• The findings underscore the importance of early detection, treatment, and prevention strategies for MetS to mitigate stroke risk.