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Updated: Jul 27, 2025

Development of an In Vitro Assay to Evaluate Contractile Function of Mesenchymal Cells that Underwent Epithelial-Mesenchymal Transition
Published on: June 10, 2016
MESENCHYME CELLS IN STARFISH DEVELOPMENT: EFFECT OF TUNICAMYCIN ON THEIR DIFFERENTIATION, MIGRATION AND FUNCTION
Marina Dan-Sohkawa1, Gakuzo Tamura2, Hiromi Mitsui3
1Stazione Zoologica di Napoli, Villa Comunale, 80121 Napoli, Italy and Department of Biology, Faculty of Science, Osaka City University, Sugimoto-cho, Sumiyoshi-ku, Osaka 558, Japan.
Abstract:
The effect of tunicamycin, an inhibitor of protein glycosylation, on starfish development was investigated. Specific developmental events such as 1) bulging of the archenteron tip, 2) migration of mesenchyme cells, 3) formation of coelomic pouches and 4) mouth formation, are inhibited in the presence of this drug. These events are discussed in connection with differentiation, migration and function of mesenchyme cells. The possibility is discussed that tunicamycin exerts its effect by interfering with de novo synthesis of a cell surface factor(s) supporting dynamic cell surface activities.
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