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Glucose-6-Phosphate Dehydrogenase Deficiency and Coronavirus Disease 2019

Ariel Israel1,2, Matitiahu Berkovitch2,3, Eugene Merzon1,4

  • 1Leumit Research Institute and Department of Family Medicine, Leumit Health Services, Tel Aviv-Yafo, Israel.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 7, 2023
PubMed

Insights

Individuals with glucose-6-phosphate dehydrogenase deficiency face higher risks for coronavirus disease 2019 (COVID-19) infection and severe outcomes. This includes increased hospitalizations and a greater likelihood of developing long COVID.

Area of Science:

  • Medical Research
  • Genetics
  • Infectious Diseases

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder.
  • The impact of G6PD deficiency on susceptibility and severity of coronavirus disease 2019 (COVID-19) remains unclear.

Purpose of the Study:

  • To investigate the association between glucose-6-phosphate dehydrogenase deficiency and COVID-19 outcomes.
  • To determine if G6PD deficiency influences infection risk, disease severity, hospitalization rates, and long COVID incidence.

Main Methods:

  • A cohort study was conducted within a national healthcare organization in Israel.
  • Data on G6PD deficiency status, COVID-19 diagnosis, hospitalization, and long COVID were analyzed.

Main Results:

  • Individuals with G6PD deficiency demonstrated an elevated risk of COVID-19 infection.
  • Higher rates of hospitalization and diagnosed long COVID were observed in the G6PD-deficient cohort.
  • G6PD deficiency was associated with increased COVID-19 severity.

Conclusions:

  • Glucose-6-phosphate dehydrogenase deficiency is linked to increased vulnerability to COVID-19.
  • Findings suggest G6PD deficiency as a potential risk factor for severe COVID-19 and long COVID complications.

Keywords:
COVID-19G6PD deficiencyglucose-6-phosphate dehydrogenase

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