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Age-related changes in left ventricular diastolic performance.

A S Iskandrian, A H Hakki

    American Heart Journal
    |July 1, 1986
    PubMed
    Summary
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    Left ventricular (LV) diastolic function declines with age, evidenced by reduced peak filling rates. This age-related decline may contribute to abnormal LV diastolic performance observed in coronary artery disease (CAD) patients.

    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • Radionuclide-derived indices of left ventricular (LV) diastolic performance are often abnormal in coronary artery disease (CAD) patients, even with normal ejection fraction (EF) and no prior myocardial infarction.
    • Age-related changes in LV diastolic function are not fully understood.

    Purpose of the Study:

    • To investigate age-related changes in LV peak filling rate and time to peak filling rate in individuals without CAD.
    • To determine if age influences LV diastolic performance metrics.

    Main Methods:

    • Sixty-five subjects (ages 20-75) with low CAD likelihood, normal resting EF (≥50%), and no prior infarction were studied.
    • Radionuclide ventriculography assessed resting and exercise LV peak filling rate and time to peak filling rate.
    • Subjects were analyzed based on age (<50 vs. ≥50 years) and hypertension history.

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    Main Results:

    • A significant age-related decline was observed in resting (r=-0.47) and exercise (r=-0.52) peak filling rates (P<0.001).
    • No age-related effect was found for time to peak filling rate.
    • Subjects ≥50 years had significantly lower resting peak filling rates compared to younger subjects (47% vs. 90%, P=0.002).
    • The age-related decline in peak filling rate was more pronounced in subjects with a history of hypertension (r=-0.66).

    Conclusions:

    • Resting and exercise peak filling rates decrease with advancing age.
    • Age differences between CAD patients and control groups may partially explain the high frequency of abnormal peak filling rates in CAD.
    • Hypertension exacerbates age-related declines in LV diastolic function.