Correlation of gut dominant microbiota with hyperuricemia

Area of Science:

• Microbiome research
• Gastroenterology
• Metabolic disease research

Background:

• Hyperuricemia is a metabolic condition associated with various health issues.
• The gut microbiome's role in metabolic diseases is an emerging area of research.
• Understanding the gut flora's influence on hyperuricemia can reveal new therapeutic targets.

Purpose of the Study:

• To investigate the correlation between dominant intestinal flora and hyperuricemia.
• To identify factors influencing the development of hyperuricemia.
• To explore the potential protective role of specific gut bacteria.

Main Methods:

• Propensity score matching used to create comparable hyperuricemia and control groups (178 pairs).
• Gut dominant microbiota composition analyzed using collected health check-up data.
• Correlation analysis (Pearson/Spearman) and logistic regression employed to assess relationships and risk factors.

Main Results:

• Hyperuricemia group showed significantly lower abundance of Atopobium, Lactobacillus, Bacteroides, Enterococcus, Clostridium leptum, Fusobacterium prausnitzii, Bifidobacterium, and Clostridium butyricum.
• Serum uric acid negatively correlated with Atopobium, Bacteroides, Clostridium leptum, Fusobacterium prausnitzii, Bifidobacterium, Eubacterium rectale, Clostridium butyricum, and the B/E ratio.
• Glutamyl transpeptidase identified as an independent risk factor, while Atopobium emerged as an independent protective factor for hyperuricemia.

Conclusions:

• Significant alterations in gut dominant microbiota are observed in individuals with hyperuricemia.
• Atopobium abundance is identified as a significant protective factor against hyperuricemia.
• These findings highlight the gut microbiome's potential role in hyperuricemia pathogenesis and management.